RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-21a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; immunohistochemistry etc.
Target
NA
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Mir-21 Promotes Cardiac Fibrosis After Myocardial Infarction Via Targeting Smad7
Year
2017
Function
"Overexpression of miR-21 promoted the effects of TGF-beta-induced activation of cardiac fibroblasts, evidenced by increased expression of col-1, alfa-SMA and f-Actin, whereas inhibition of miR-21 attenuated the process of fibrosis."